Liquid chromatography–mass spectrometry (LC-MS)

Definition:

Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). LC-MS may be applied in a wide range of sectors including biotechnology, environment monitoring, food processing, and pharmaceutical, agrochemical, and cosmetic industries.

References:

[1]. López-Fernández O, et al. Determination of Polyphenols Using Liquid Chromatography-Tandem Mass Spectrometry Technique (LC-MS/MS): A Review. Antioxidants (Basel). 2020 Jun 2;9(6):479. [Content Brief]

[2]. Famiglini G, et al. The history of electron ionization in LC-MS, from the early days to modern technologies: A review. Anal Chim Acta. 2021 Jul 4;1167:338350. [Content Brief]

[3]. Beccaria M , et al. Current developments in LC-MS for pharmaceutical analysis. Analyst. 2020 Feb 17;145(4):1129-1157. [Content Brief]

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