Long-chain-fatty-acid--CoA ligase ACSBG1

Definition:

Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.

References:

[1]. Aya Ohkuni, et al. Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. Biochem Biophys Res Commun. 2013 Dec 13;442(3-4):195-201. [Content Brief]

[2]. Zhengtong Pei, et al. The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. J Biol Chem. 2003 Nov 21;278(47):47070-8. [Content Brief]

[3]. S J Steinberg, et al. Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids. J Biol Chem. 2000 Nov 10;275(45):35162-9. [Content Brief]

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