Low-density lipoprotein receptor class A domain-containing protein 3

Definition:

May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation.; (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.

References:

[1]. Hongming Ma, et al. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Nature. 2020 Dec;588(7837):308-314. [Content Brief]

[2]. Bingting Ma, et al. Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3. Nature. 2021 Oct;598(7882):677-681. [Content Brief]

[3]. Nathaniel C Noyes, et al. Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. Biochemistry. 2016 Mar 1;55(8):1204-13. [Content Brief]

[4]. Katherine Basore, et al. Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor. Nature. 2021 Oct;598(7882):672-676. [Content Brief]

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