Low molecular weight phosphotyrosine protein phosphatase

Definition:

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.; [Isoform 3]: Does not possess phosphatase activity.

References:

[1]. M Zhang, et al. Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. J Biol Chem. 1998 Aug 21;273(34):21714-20. [Content Brief]

[2]. P Tailor, et al. A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing. Eur J Biochem. 1999 Jun;262(2):277-82. [Content Brief]

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