Ly6/PLAUR domain-containing protein 6

Definition:

Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).

References:

[1]. Maria Arvaniti, et al. Functional interaction between Lypd6 and nicotinic acetylcholine receptors. J Neurochem. 2016 Sep;138(6):806-20. [Content Brief]

[2]. Dmitrii Kulbatskii, et al. Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain. Front Cell Dev Biol. 2021 Sep 21;9:662227. [Content Brief]

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