Ly6/PLAUR domain-containing protein 6
Definition:
Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
References:
-
[1]. Maria Arvaniti, et al. Functional interaction between Lypd6 and nicotinic acetylcholine receptors. J Neurochem. 2016 Sep;138(6):806-20. [Content Brief]
[2]. Dmitrii Kulbatskii, et al. Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain. Front Cell Dev Biol. 2021 Sep 21;9:662227. [Content Brief]
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
