Lysine specific demethylase 1 (LSD1)

Definition:

Lysine-specific demethylase 1(LSD1) also known as KDM1A, is the first discovered histone lysine demethylase. LSD1 has the ability to demethylase H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. LSD1 regulates the balance between self-renewal and differentiation of stem cells. LSD1 is highly expressed in various cancers and mediates differentiation and self-renewal of tumor cells.

References:

[1]. Hosseini A, et al. A comprehensive review of lysine-specific demethylase 1 and its roles in cancer. Epigenomics. 2017 Aug;9(8):1123-1142. [Content Brief]

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