Lysophospholipase-like protein 1

Definition:

Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.

References:

[1]. Lijun Tian, et al. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. J Biol Chem. 2012 Apr 27;287(18):14718-25. [Content Brief]

[2]. Marco Bürger, et al. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases. J Lipid Res. 2012 Jan;53(1):43-50. [Content Brief]

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