Lysosomal amino acid transporter 1 homolog

Definition:

Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.

References:

[1]. Bin Liu, et al. LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science. 2012 Jul 20;337(6092):351-4. [Content Brief]

[2]. Adrien Jézégou, et al. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3434-43. [Content Brief]

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