Mannose-binding protein C

Definition:

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response.

References:

[1]. Alma J Nauta, et al. Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol. 2003 Oct;33(10):2853-63. [Content Brief]

[2]. Matteo Stravalaci, et al. Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules. Nat Immunol. 2022 Feb;23(2):275-286. [Content Brief]

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