Megakaryocyte and platelet inhibitory receptor G6b

Definition:

Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner.; Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.

References:

[1]. Motasem Melhem, et al. Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia. Eur J Haematol. 2017 Mar;98(3):218-227. [Content Brief]

[2]. Stephen A Newland, et al. The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. Blood. 2007 Jun 1;109(11):4806-9. [Content Brief]

[3]. Kris Gevaert, et al. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. [Content Brief]

[4]. E C de Vet, et al. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. J Biol Chem. 2001 Nov 9;276(45):42070-6. [Content Brief]

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