Methionine synthase

Definition:

Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.

References:

[1]. Kirsten R Wolthers, et al. Crystal structure and solution characterization of the activation domain of human methionine synthase. FEBS J. 2007 Feb;274(3):738-50. [Content Brief]

[2]. Kazuhiro Yamada, et al. Human methionine synthase reductase is a molecular chaperone for human methionine synthase. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9476-81. [Content Brief]

[3]. Christine Bassila, et al. Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):103-112. [Content Brief]

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