MICAL-like protein 1

Definition:

Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.

References:

[1]. Nancy Abou-Zeid, et al. MICAL-like1 mediates epidermal growth factor receptor endocytosis. Mol Biol Cell. 2011 Sep;22(18):3431-41. [Content Brief]

[2]. Mahak Sharma, et al. MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling. Mol Biol Cell. 2009 Dec;20(24):5181-94. [Content Brief]

[3]. Sai Srinivas Panapakkam Giridharan, et al. Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. Mol Biol Cell. 2013 Jun;24(11):1776-90, S1-15. [Content Brief]

[4]. Juliati Rahajeng, et al. Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem. 2010 Oct 15;285(42):31918-22. [Content Brief]

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