MICOS complex subunit MIC19
Definition:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
References:
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[1]. Hongyu Liu, et al. Cloning and functional analysis of FLJ20420: a novel transcription factor for the BAG-1 promoter. PLoS One. 2012;7(5):e34832. [Content Brief]
[2]. Christine Ott, et al. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS One. 2015 Mar 17;10(3):e0120213. [Content Brief]
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