Migration and invasion enhancer 1

Definition:

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

References:

[1]. S Dasgupta, et al. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. Oncogene. 2009 Aug 13;28(32):2860-72. [Content Brief]

[2]. Subhamoy Dasgupta, et al. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem. 2011 Jul 22;286(29):25935-46. [Content Brief]

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