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Mild encephalopathy with reversible myelin vacuolization

Definition:

Mild encephalopathy with reversible myelin vacuolization (MMERV) is a familial disorder with clinical finding of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). Mutations in MYRF have been identified in patients. MYRF is a critical transcriptional regulator required for CNS myelination.

References:

[1]. Matthias Koenning, et al. Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. J Neurosci. 2012 Sep 5;32(36):12528-42. [Content Brief]

[2]. Takuji Imamura, et al. Sisters with clinically mild encephalopathy with a reversible splenial lesion (MERS)-like features; Familial MERS?. J Neurol Sci. 2010 Mar 15;290(1-2):153-6. [Content Brief]

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