Mitochondrial assembly of ribosomal large subunit protein 1

Definition:

Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor (Probable).

References:

[1]. Roman Häuser, et al. RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS Genet. 2012;8(7):e1002815. [Content Brief]

[2]. Alan Brown, et al. Structures of the human mitochondrial ribosome in native states of assembly. Nat Struct Mol Biol. 2017 Oct;24(10):866-869. [Content Brief]

[3]. Joanna Rorbach, et al. C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome. Nucleic Acids Res. 2012 May;40(9):4097-109. [Content Brief]

[4]. Bas F J Wanschers, et al. C7orf30 specifically associates with the large subunit of the mitochondrial ribosome and is involved in translation. Nucleic Acids Res. 2012 May;40(9):4040-51. [Content Brief]

[5]. Stephen Fung, et al. The conserved interaction of C7orf30 with MRPL14 promotes biogenesis of the mitochondrial large ribosomal subunit and mitochondrial translation. Mol Biol Cell. 2013 Feb;24(3):184-93. [Content Brief]

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