Mitochondrial calcium uniporter regulator 1

Definition:

Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex).

References:

[1]. Horia Vais, et al. MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter. Cell Metab. 2015 Oct 6;22(4):533-5. [Content Brief]

[2]. Dhanendra Tomar, et al. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Cell Rep. 2016 May 24;15(8):1673-85. [Content Brief]

[3]. Karthik Mallilankaraman, et al. MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol. 2012 Dec;14(12):1336-43. [Content Brief]

[4]. Dipayan Chaudhuri, et al. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1872-80. [Content Brief]

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