Mitochondrial dynamics protein MID49

Definition:

Mitochondrial outer membrane protein involved in the regulation of mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.

References:

[1]. Catherine S Palmer, et al. MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep. 2011 Jun;12(6):565-73. [Content Brief]

[2]. Raghav Kalia, et al. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018 Jun;558(7710):401-405. [Content Brief]

[3]. Oliver C Losón, et al. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell. 2013 Mar;24(5):659-67. [Content Brief]

[4]. Marina Bartsakoulia, et al. A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies. Hum Mol Genet. 2018 Apr 1;27(7):1186-1195. [Content Brief]

[5]. Sajjan Koirala, et al. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1342-51. [Content Brief]

[6]. Catherine S Palmer, et al. Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem. 2013 Sep 20;288(38):27584-27593. [Content Brief]

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