Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

Definition:

Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria.

References:

[1]. Timothy S Luongo, et al. SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature. 2020 Dec;588(7836):174-179. [Content Brief]

[2]. Enrico Girardi, et al. Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. Nat Commun. 2020 Dec 1;11(1):6145. [Content Brief]

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