Mitogen-activated protein kinase kinase kinase 6

Definition:

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

References:

[1]. X S Wang, et al. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. Biochem Biophys Res Commun. 1998 Dec 9;253(1):33-7. [Content Brief]

[2]. Kohsuke Takeda, et al. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J Biol Chem. 2007 Mar 9;282(10):7522-31. [Content Brief]

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