Monocarboxylate transporter 2

Definition:

Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate. Dimerization is functionally required and both subunits work cooperatively in transporting substrate.

References:

[1]. Bo Zhang, et al. Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun. 2020 May 15;11(1):2429. [Content Brief]

[2]. R Y Lin, et al. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. [Content Brief]

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