Multidrug-resistant (MDR)

Definition:

Multidrug-resistant (MDR) refers to a situation in which the disease becomes resistant to drug treatment, and once resistance develops, the effect of the drug is significantly reduced or no longer works at all. When an organism develops resistance to multiple drugs, it is called multidrug-resistant (MDR). Resistance results from kinase mutations that interfere with inhibitor binding without compromising kinase function.

References:

[1]. Priya Kannian, et al. Carbapenem-Resistant Gram Negative Bacilli Are Predominantly Multidrug or Pan-Drug Resistant. Microb Drug Resist. 2021 Aug;27(8):1057-1062. [Content Brief]

[2]. Ralph Tiedt, et al. A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. Cancer Res. 2011 Aug 1;71(15):5255-64. [Content Brief]

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