Multidrug-resistant (MDR)

Definition:

Multidrug-resistant (MDR) refers to a situation in which the disease becomes resistant to drug treatment, and once resistance develops, the effect of the drug is significantly reduced or no longer works at all. When an organism develops resistance to multiple drugs, it is called multidrug-resistant (MDR). Resistance results from kinase mutations that interfere with inhibitor binding without compromising kinase function.

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