Myeloblastin

Definition:

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.

References:

[1]. Uwe Jerke, et al. Characterization of the CD177 interaction with the ANCA antigen proteinase 3. Sci Rep. 2017 Feb 27;7:43328. [Content Brief]

[2]. Christopher J Kuckleburg, et al. Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. J Immunol. 2012 Mar 1;188(5):2419-26. [Content Brief]

[3]. R C Kao, et al. Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J Clin Invest. 1988 Dec;82(6):1963-73. [Content Brief]

[4]. N V Rao, et al. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. J Biol Chem. 1991 May 25;266(15):9540-8. [Content Brief]

[5]. Christopher J Kuckleburg, et al. Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):275-84. [Content Brief]

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