Myeloid differentiation primary response protein MyD88

Definition:

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.

References:

[1]. Takahiro Yamamoto, et al. Functional assessment of the mutational effects of human IRAK4 and MyD88 genes. Mol Immunol. 2014 Mar;58(1):66-76. [Content Brief]

[2]. T P Bonnert, et al. The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. FEBS Lett. 1997 Jan 27;402(1):81-4. [Content Brief]

[3]. Yoon Jeong Choi, et al. TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem. 2010 Nov 26;285(48):37570-8. [Content Brief]

[4]. Noha Semaan, et al. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. J Immunol. 2008 Mar 1;180(5):3485-91. [Content Brief]

[5]. Hidenori Ohnishi, et al. Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10260-5. [Content Brief]

[6]. Taro Kawai, et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004 Oct;5(10):1061-8. [Content Brief]

[7]. Grant R Campbell, et al. SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway. iScience. 2021 Apr 23;24(4):102295. [Content Brief]

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