Myomegalin

Definition:

Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).; [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression.

References:

[1]. Jingchao Wu, et al. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Dev Cell. 2016 Oct 10;39(1):44-60. [Content Brief]

[2]. Chao Yang, et al. EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. J Cell Biol. 2017 Oct 2;216(10):3179-3198. [Content Brief]

[3]. Zhe Wang, et al. A newly identified myomegalin isoform functions in Golgi microtubule organization and ER-Golgi transport. J Cell Sci. 2014 Nov 15;127(Pt 22):4904-17. [Content Brief]

[4]. Habib Bouguenina, et al. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10687-E10696. [Content Brief]

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