N-acetyltransferase ESCO1

Definition:

Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.

References:

[1]. Marie-Emilie Terret, et al. Cohesin acetylation speeds the replication fork. Nature. 2009 Nov 12;462(7270):231-4. [Content Brief]

[2]. Jinglan Zhang, et al. Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell. 2008 Jul 11;31(1):143-51. [Content Brief]

[3]. Ekaterina Kouznetsova, et al. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Structure. 2016 May 3;24(5):789-796. [Content Brief]

[4]. Fajian Hou, et al. Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion. Mol Biol Cell. 2005 Aug;16(8):3908-18. [Content Brief]

[5]. Yadilette Rivera-Colón, et al. Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1. J Biol Chem. 2016 Dec 16;291(51):26468-26477. [Content Brief]

[6]. Aaron M Bellows, et al. Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains. Nucleic Acids Res. 2003 Nov 1;31(21):6334-43. [Content Brief]

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