N-acylglucosamine 2-epimerase

Definition:

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

References:

[1]. S Takahashi, et al. Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase. J Biochem. 1999 Feb;125(2):348-53. [Content Brief]

[2]. Sarah J Luchansky, et al. GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism. J Biol Chem. 2003 Mar 7;278(10):8035-42. [Content Brief]

[3]. S Takahashi, et al. Identification of cysteine-380 as the essential residue for the human N-acetyl-D-glucosamine 2-epimerase (renin binding protein). J Biochem. 1999 Oct;126(4):639-42. [Content Brief]

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