N-alpha-acetyltransferase 40

Definition:

N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'. Acts as a negative regulator of apoptosis. May play a role in hepatic lipid metabolism (By similarity).

References:

[1]. Robert S Magin, et al. The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. Structure. 2015 Feb 3;23(2):332-41. [Content Brief]

[2]. Kristine Hole, et al. The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. PLoS One. 2011;6(9):e24713. [Content Brief]

[3]. Demetria Pavlou, et al. Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. Apoptosis. 2016 Mar;21(3):298-311. [Content Brief]

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