N-alpha-acetyltransferase 80

Definition:

N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor.

References:

[1]. Elsa Wiame, et al. NAT6 acetylates the N-terminus of different forms of actin. FEBS J. 2018 Sep;285(17):3299-3316. [Content Brief]

[2]. P Zegerman, et al. The putative tumour suppressor Fus-2 is an N-acetyltransferase. Oncogene. 2000 Jan 6;19(1):161-3. [Content Brief]

[3]. Adrian Drazic, et al. NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4399-4404. [Content Brief]

[4]. Marianne Goris, et al. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4405-4410. [Content Brief]

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