N-terminal EF-hand calcium-binding protein 3

Definition:

Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.

References:

[1]. D S Lee, et al. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem. 2000 Jul 28;275(30):23134-8. [Content Brief]

[2]. Hiroki J Nakaoka, et al. NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells. Sci Rep. 2016 Mar 7;6:22784. [Content Brief]

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