N-terminal Xaa-Pro-Lys N-methyltransferase 2

Definition:

Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation.

References:

[1]. Janusz J Petkowski, et al. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. Biochem J. 2013 Dec 15;456(3):453-62. [Content Brief]

[2]. Cheng Dong, et al. An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Commun Biol. 2018 Nov 2;1:183. [Content Brief]

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