NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Definition:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.

References:

[1]. Yang Ni, et al. Mutations in NDUFS1 Cause Metabolic Reprogramming and Disruption of the Electron Transfer. Cells. 2019 Sep 25;8(10):1149. [Content Brief]

[2]. Rana Elkholi, et al. MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network. Mol Cell. 2019 May 2;74(3):452-465.e7. [Content Brief]

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