Necroptosis

Definition:

Necroptosis is a regulated necrotic cell death modality in a caspase-independent fashion and is mainly mediated by Receptor-Interacting Protein 1 (RIP1), RIP3, and Mixed Lineage Kinase Domain-Like (MLKL). Necroptosis serves as an alternative mode of Programmed cell death (PCD) overcoming apoptosis resistance.

References:

[1]. Yitao Gong, et al. The role of necroptosis in cancer biology and therapy. Mol Cancer. 2019 May 23;18(1):100. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

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