Negative allosteric modulator (NAM)

Definition:

Negative allosteric modulators (NAMs) represent a novel and indirect approach to attenuate signaling by decreasing affinity and/or efficacy of ligands.

References:

[1]. Vishakh Iyer, et al. Negative allosteric modulation of CB1 cannabinoid receptor signaling suppresses opioid-mediated reward. Pharmacol Res. 2022 Nov;185:106474. [Content Brief]

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