Negative elongation factor E
Definition:
References:
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[1]. Seychelle M Vos, et al. Architecture and RNA binding of the human negative elongation factor. Elife. 2016 Jun 10;5:e14981. [Content Brief]
[2]. Y Yamaguchi, et al. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell. 1999 Apr 2;97(1):41-51. [Content Brief]
[3]. Bryan A Gibson, et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353(6294):45-50. [Content Brief]
[4]. Jampani Nageswara Rao, et al. NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding. Biochemistry. 2008 Mar 25;47(12):3756-61. [Content Brief]
[5]. Takashi Narita, et al. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Mol Cell Biol. 2003 Mar;23(6):1863-73. [Content Brief]
[6]. Malini Natarajan, et al. Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013 Sep 6;288(36):25995-26003. [Content Brief]
[7]. Yuki Yamaguchi, et al. Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol Cell Biol. 2002 May;22(9):2918-27. [Content Brief]
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