Neuralized-like protein 4

Definition:

Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

References:

[1]. Ji Li, et al. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. EMBO Rep. 2012 Jun 1;13(6):547-53. [Content Brief]

[2]. Abdallah K Al-Hakim, et al. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. Mol Cell Proteomics. 2012 Jun;11(6):M111.014233. [Content Brief]

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