Neuraminidase (NA)

Definition:

Neuraminidase (NA), also known as sialidase, is a glycoprotein distributed on the membrane of influenza virus. It can catalyze the hydrolysis of sialic acid. Neuraminidase also significantly deglycosylated and degraded lysosomal associated membrane proteins, inducing lysosomal rupture.

References:

[1]. Zhang JY, et al. Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases. Am J Chin Med. 2021;49(4):843-862. [Content Brief]

[2]. Ju X, et al. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. J Virol. 2015 Oct;89(20):10347-58. [Content Brief]

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