Neuroendocrine convertase 2

Definition:

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

References:

[1]. Y Rouillé, et al. Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon. FEBS Lett. 1997 Aug 11;413(1):119-23. [Content Brief]

[2]. Alexandra Winters, et al. Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population. Diabetes Res Clin Pract. 2017 Sep;131:82-90. [Content Brief]

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