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Neuroglobin

Definition:

Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

References:

[1]. T Burmester, et al. A vertebrate globin expressed in the brain. Nature. 2000 Sep 28;407(6803):520-3. [Content Brief]

[2]. Thomas Brittain, et al. A role for human neuroglobin in apoptosis. IUBMB Life. 2010 Dec;62(12):878-85. [Content Brief]

[3]. Seiji Watanabe, et al. Zebrafish neuroglobin is a cell-membrane-penetrating globin. Biochemistry. 2008 May 13;47(19):5266-70. [Content Brief]

[4]. Mauro Tiso, et al. Human neuroglobin functions as a redox-regulated nitrite reductase. J Biol Chem. 2011 May 20;286(20):18277-89. [Content Brief]

[5]. S Dewilde, et al. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J Biol Chem. 2001 Oct 19;276(42):38949-55. [Content Brief]

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