Neuropeptide S receptor

Definition:

G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.

References:

[1]. Yan-Ling Xu, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004 Aug 19;43(4):487-97. [Content Brief]

[2]. Johanna Vendelin, et al. Characterization of GPRA, a novel G protein-coupled receptor related to asthma. Am J Respir Cell Mol Biol. 2005 Sep;33(3):262-70. [Content Brief]

[3]. Virginie Bernier, et al. Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. J Biol Chem. 2006 Aug 25;281(34):24704-12. [Content Brief]

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