Neuroserpin

Definition:

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).

References:

[1]. Stefano Ricagno, et al. Human neuroserpin: structure and time-dependent inhibition. J Mol Biol. 2009 Apr 24;388(1):109-21. [Content Brief]

[2]. Rosina Noto, et al. The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop. Sci Rep. 2015 Sep 2;5:13666. [Content Brief]

[3]. T Osterwalder, et al. The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin. J Biol Chem. 1998 Jan 23;273(4):2312-21. [Content Brief]

[4]. Sayaka Takehara, et al. The 2.1-A crystal structure of native neuroserpin reveals unique structural elements that contribute to conformational instability. J Mol Biol. 2009 Apr 24;388(1):11-20. [Content Brief]

[5]. Didier Belorgey, et al. Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro. J Biol Chem. 2002 May 10;277(19):17367-73. [Content Brief]

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