Neutrophil elastase

Definition:

Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae.

References:

[1]. A Belaaouaj, et al. Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. Science. 2000 Aug 18;289(5482):1185-8. [Content Brief]

[2]. Tim Tralau, et al. Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis. Exp Dermatol. 2004 May;13(5):316-25. [Content Brief]

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