NF-kappa-B-activating protein

Definition:

Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.

References:

[1]. Danying Chen, et al. Identification of a nuclear protein that promotes NF-kappaB activation. Biochem Biophys Res Commun. 2003 Oct 24;310(3):720-4. [Content Brief]

[2]. Anthony G Pajerowski, et al. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. Immunity. 2009 May;30(5):696-707. [Content Brief]

[3]. Sarah K Fiordaliso, et al. Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment. Am J Hum Genet. 2019 Nov 7;105(5):987-995. [Content Brief]

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