2. Biology Dictionary
  3. NF-kappa-B inhibitor alpha

NF-kappa-B inhibitor alpha

Definition:

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Biomedical Dictionary

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