NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

Definition:

Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins.

References:

[1]. Kai Cai, et al. Structural/Functional Properties of Human NFU1, an Intermediate [4Fe-4S] Carrier in Human Mitochondrial Iron-Sulfur Cluster Biogenesis. Structure. 2016 Dec 6;24(12):2080-2091. [Content Brief]

[2]. Wing-Hang Tong, et al. Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9762-7. [Content Brief]

[3]. Nathaniel A Wesley, et al. Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1. FEBS J. 2017 Nov;284(22):3838-3848. [Content Brief]

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