Nicotinate phosphoribosyltransferase

Definition:

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.

References:

[1]. Ada Serena Marletta, et al. Crystal structure of human nicotinic acid phosphoribosyltransferase. FEBS Open Bio. 2015 May 7;5:419-28. [Content Brief]

[2]. Nobumasa Hara, et al. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. J Biol Chem. 2007 Aug 24;282(34):24574-82. [Content Brief]

[3]. Lucia Galassi, et al. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie. 2012 Feb;94(2):300-9. [Content Brief]

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