Ninein-like protein

Definition:

Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.

References:

[1]. Martina Casenghi, et al. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell. 2003 Jul;5(1):113-25. [Content Brief]

[2]. Danni Qu, et al. Increased expression of Nlp, a potential oncogene in ovarian cancer, and its implication in carcinogenesis. Gynecol Oncol. 2008 Aug;110(2):230-6. [Content Brief]

[3]. Martina Casenghi, et al. Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. J Cell Sci. 2005 Nov 1;118(Pt 21):5101-8. [Content Brief]

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