NMDA receptor synaptonuclear signaling and neuronal migration factor

Definition:

Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.

References:

[1]. Ning Xu, et al. NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration. Mol Cell Endocrinol. 2010 May 5;319(1-2):47-55. [Content Brief]

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