Non-receptor tyrosine-protein kinase TYK2
Definition:
References:
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[1]. Raffaele Mori, et al. TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity. Sci Rep. 2017 Nov 21;7(1):15919. [Content Brief]
[2]. C M Bacon, et al. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7307-11. [Content Brief]
[3]. M Müller, et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature. 1993 Nov 11;366(6451):129-35. [Content Brief]
[4]. A Kusch, et al. Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction. J Biol Chem. 2000 Dec 15;275(50):39466-73. [Content Brief]
[5]. O Colamonici, et al. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol. 1994 Dec;14(12):8133-42. [Content Brief]
[6]. John S Tokarski, et al. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. J Biol Chem. 2015 Apr 24;290(17):11061-74. [Content Brief]
[7]. F W Quelle, et al. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J Biol Chem. 1995 Sep 1;270(35):20775-80. [Content Brief]
[8]. C Abramovich, et al. Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta. EMBO J. 1994 Dec 15;13(24):5871-7. [Content Brief]
[9]. M R Rani, et al. Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. J Biol Chem. 1999 Nov 5;274(45):32507-11. [Content Brief]
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