Nonsense-mediated mRNA decay factor SMG7

Definition:

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

References:

[1]. Noemi Fukuhara, et al. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell. 2005 Feb 18;17(4):537-47. [Content Brief]

[2]. Leonie Unterholzner, et al. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell. 2004 Nov 19;16(4):587-96. [Content Brief]

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